Buccaline

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Buccaline is an inactivated whole cell vaccine for oral application. The constituent bacteria are very often found as pathogens in colds and chills.
On contact with the bacterial surface antigens contained in Buccaline, the differentiation and maturation of immunocompetent lymphocytes are specifically stimulated.
Pharmacokinetics
The tablets have a coating that is resistant to gastric juice. After dissolution in the small intestine, the bacterial antigens undergo phagocytosis by macrophages found in the intestinal wall and then pass with them into the local reticuloendothelial tissue, where they stimulate the immune system to build up a systemic, specific immunity.
Indications
Oral antibacterial prophylaxis of complications of colds.
Dosage and Administration
The tablets are to be swallowed whole with some fluid, best one hour before breakfast or one hour before the midday meal.
Children under 7 years of age are given one tablet on the first and second day and two tablets on the third day.
Children over 7 years of age and adults receive one tablet on the first day, two tablets on the second and four tablets on the third day.
Contraindications
There are no known contraindications.
Warnings and Precautions
Vaccinations should not be given during acute febrile illnesses. Buccaline is not intended as an alternative to influenza vaccination and does not offer protection against viral coughs and colds. Buccaline may be used as an adjunct to influenza vaccination.
Use in Pregnancy
Pregnancy category C: oral inactivated vaccines are not, in principle, contraindicated in pregnancy. However, as neither controlled studies in animals nor in pregnant women have been undertaken, Buccaline should only be given if the potential benefits outweigh the possible risks.
Use in Lactation
Administration of Buccaline during breast-feeding has no negative effects on the child.